Plasma sCD14 as a Biomarker to Predict Pulmonary Exacerbations in Cystic Fibrosis
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چکیده
منابع مشابه
Plasma sCD14 as a Biomarker to Predict Pulmonary Exacerbations in Cystic Fibrosis
BACKGROUND One in four cystic fibrosis (CF) patients diagnosed with a pulmonary exacerbation will not recover their baseline lung function despite standard treatment. This highlights the importance of preventing such events. Clinical decision-making can be improved through a simple blood test that predicts individuals at elevated short-term risk of an exacerbation. METHODS We obtained plasma ...
متن کاملTreatment of pulmonary exacerbations in cystic fibrosis.
Pulmonary exacerbations have very important consequences in cystic fibrosis (CF), both in terms of current morbidity as well as implications for long term morbidity and mortality. Even though there is no universally agreed definition of pulmonary exacerbation, prompt and aggressive treatment with a multidisciplinary approach is recommended. Maintenance treatments reduce the risk of exacerbation...
متن کاملPulmonary exacerbations in cystic fibrosis and bronchiectasis.
unique characteristics. Taking these characteristics into account should enable a more accurate assessment of disease severity. Numerous examples exist of disease-specific scores that outperform generic scores, 14 including the PSI in the context of patients hospitalised with CAP. The study by Barlow et al extends this view to CURB65 in relation to SEWS and SIRS. However, the patient cohort in ...
متن کاملClinical utility of C-reactive protein to predict treatment response during cystic fibrosis pulmonary exacerbations
RATIONALE C-reactive protein (CRP) is a systemic marker of inflammation that correlates with disease status in cystic fibrosis (CF). The clinical utility of CRP measurement to guide pulmonary exacerbation (PEx) treatment decisions remains uncertain. OBJECTIVES To determine whether monitoring CRP during PEx treatment can be used to predict treatment response. We hypothesized that early changes...
متن کاملIP-10 Is a Potential Biomarker of Cystic Fibrosis Acute Pulmonary Exacerbations
BACKGROUND Cystic fibrosis (CF) is characterized by acute pulmonary exacerbations (APE). The CF nasal airway exhibits a similar ion transport defect as the lung, and colonization, infection, and inflammation within the nasal passages are common among CF patients. Nasal lavage fluid (NLF) is a minimally invasive means to collect upper airway samples. METHODS We collected NLF at the onset and r...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0089341